Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.
نویسندگان
چکیده
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
منابع مشابه
The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors.
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ورودعنوان ژورنال:
- Journal of neurochemistry
دوره 82 6 شماره
صفحات -
تاریخ انتشار 2002